In information system research, research focusing on the practice of IT artifacts has received muchattention. One perspective is the idea of “design science.” The focus of Design Science is a research on IT artifacts developed based on Simonʼs seminal book “The Science of the artifacts”. However, there is no consensus on the idea of digital science, and there is confusion over the perspectives. Therefore, in this paper, in order to unravel conceptual confusion of design science, the author conduct a comprehensive review of previous studies with two keywords “design” and “science” as clues.