抄録
The primitive roles of neutrophils are known as phagocyte to engulf and kill microorganisms which invade human bodies. Recently, it is well established that neutrophils play important roles to modulate inflammation. Clearance of apoptotic neutrophils by cells such as macrophages can lead to the resolution of inflammation. It is also important to clarify the mechanisms of neutrophilic inflammation and to develop therapeutic strategies based on the induction of neutrophil apoptosis in order to reverse or attenuate an inflammatory response. Several modulators of neutrophil apoptosis and activators of neutrophil priming have been discovered, they have been discussed in the pathogenesis of several diseases. However, we have no potential therapeutic strategy on the property so far. New clinical perspectives in future are expected.
