血漿プレカリクレイン, カリクレン, プロテアーゼ・インヒビター

抄録

I measured serum protease inhibitors, α_l-antitrypsin, α_l-antichymotrypsin, α₂-macroglobulin, C 1 inactivator and inter-alpha-trypsin inhibitor by single radial immunodiffusion. I studied 15 normal controls and 52 patients with Behcet's disease.
In serum α_l-antitrypsin, α_l-antichymotrypsis, and inter-alpha-trypsin inhibitor showed an increase over normal controls, but the other protease inhibitors showed sligh increase.
A chromogenic sythetic tripeptide (Chrozym PK) was used as a substrate for kallikrein.
There was a tendency to low plasma kallikreinin in Behcet's disease. There was no correlation between plasma prekallikrein and CRP. The values of plasma kallikrein/ prekallikrein showed a sharp rise as plasma C 1 inactivator level was over about 40 mg/dl.