抄録
Recently prodrugs are developed in various kinds of medicines. These prodruges are absorbed from gastrointestinal tract in inactive forms, and then converted to active forms mainly in the liver. In the field of non-steroid anti-inflammatory drugs, prodrugs are also being developed.
Using carrageenin edema method, we evaluated the four produrugs : Fenbufen, Sulindac, Suxybuzone and Acemethacine. By local Administratior, prodrugs show less antiinflammatory effects than active metabolites.
Then we discussed the appearance of side effects in the data of clinical trials carried out at many institutes. We found that the administration of prodrugs cause less side effects, especially the gastrointestinal ones, than that of active drugs.
