抄録
In order to investigate the usefulness of the clamping method as an inflammation model, the healing process of clamp-induced gastric muco-muscular defects in rats were observed. Furthermore, the effects of several antiinflammatory drugs on the healing process were studied quantitatively.
Male Wistar rats weighing 200-250 gm. were used. An acute gastric muco-muscular defect was produced with a special 12 × 4 mm metal clamp applied for 24 hours. Tested drugs were given 7 days after clamping.
Histological findings showed inflammations such as submucosal edema, and infiltration of polymorpho-nuclear cells in the margin of the mucosal defect in the early phase while granulation was observed in the base of the mucosal defect in the late phase.
The tested anti-inflammatory drugs adversely influenced the gastric muco-muscular defect in the following ways. Cortisone acetate inhibited mucosal regeneration and granulation while prednisolone and indomethacine inhibited only the mucosal regeneration. Aspirin and phenylbutazone inhibited regeneration to a lesser degree. D-penicillamine didn't have any adverse effects on either regeneration or granulation.
The clamping method is useful as an inflammation model as well as a way to check the adverse effects of anti-inflammatory drugs.
