Abstract
The effect of mizoribine (MZR) on adjuvant and collagen arthritis in rats is investigated. In adjuvant arthritis, twice daily doses of 2.5 and 5 mg/kg of mizoribine showed a marked inhibition of the development of secondary lesions of arthritis comparing to the corresponding single daily doses of 5 and 10 mg/kg.
In the case of collagen arthritis, the treatment for 21 days at dose of 10 mg/kg daily, begun on the next day of the bovine type II collagen immunization, suppressed the development of arthritis as well as humoral antibody response to collagen. Although mizoribine treatment only during the induction phase of immunity proved to be successful, the treatment during the established phase of immunity only delayed the development of arthritis.
