Ensho
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
Participation of reactive oxygen metabolites in progression of glomerulonephritis: effect of para-amino benzoate sodium mannoside on renal damage caused by phorbol myristate acetate
Tsutomu SanakaMasako OmataTakako SatoChieko HiguchiMegumi NishikawaNobuhiro SuginoYukako IshidaShinji NakajimaMasanori TogawaMasanori Ikuzawa
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JOURNAL FREE ACCESS

1990 Volume 10 Issue 4 Pages 279-285

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Abstract
To the recent knowledge, it is possibly speculated that reactive oxygen metabolites (ROM) play a key role in the initiation and progression of glomerulonephritis. The present study was aimed to clarify where ROM are produced in the renal tissue, and whether para-amino benzoate sodium Mannoside, which is named K-MAP bring about a therapeutic effect on renal damage caused by ROM or not. The production of ROM was induced with the injection of 20-40 μg/animal of phorbol myristate acetate (PMA) .
The injection of PMA lead to massive proteinuria with severe morphological alterations in glomeruli and tubuli. ROM were visualized out in the glomerular and tubular cells by means of celium chloride staining method. K-MAP demonstrated significant effects against the proteinuria and pathological changes in the glomerulus of the experimental model.
From these results, we suggest that ROM participate in the progression of renal injury due to glomerulonephritis and K-MAP may have a therapeutic effect on it.
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© The Japanese Society of Inflammation and Regeneration
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