Ensho
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
Effect of glycyrrhizin on the production of platelet-activating factor from mouse hepatic sinusoidal endothelial cells
Yuzo Ichikawa, Yasuhiro Mizoguchi, Kiyohide Kioka, Kenzo Kobayashi, Kiyoko Tomekawa, Seiji Morisawa, Sukeo Yamamoto
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Keywords: glycyrrhizin, platelet-activating factor, hepatic sinusoidal endothelial cells
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1990 Volume 10 Issue 4 Pages 275-278

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Abstract
We examined the effect of glycyrrhizin (GL) on the production of platelet-activating factor (PAF) from mouse hepatic sinusoidal endothelial cells. GL was shown to significantly suppress the production of PAF from the mouse sinusoidal endothelial cells stimulated with calcium ionophore A 23187.
This result suggests that GL may act on sinusoidal endothelial cells and have an influence on the local hepatic inflammatory reactions by the suppression of PAF production.
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© The Japanese Society of Inflammation and Regeneration
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