Abstract
Anti-inflammatory effect of iodine-enriched egg was evaluated against ear inflammation produced in mice by arachidonic acid and the following results were obtained. (1) High concentration iodine-enriched egg (287 ppm iodine) suppressed ear edema caused by arachidonic acid-induced inflammation in mice by oral administration for 10 days prior to chemical injury. (2) In addition, low concentration iodine-enriched egg (70 ppm iodine) was also effective by administration orally for 30 days prior to the injury. (3) Nordihydroguaiaretic acid was the most effective to suppress ear edema by topical application. (4) Oral administration of aspirin and ordinary egg (less than 3.5 ppm iodine) were not effective. (5) An increase was induced in serum corticosterone levels by feeding of iodine-enriched egg for 10 days.
These results suggested that iodine-enriched egg suppress ear edema in mice by possibly influencing on arachidonic acid metabolism and pituitary adrenal system.
