Abstract
The Kampo drugs, Saireito, Ninjinyoueito and Kamikihito, inhibited significantly the development of hind foot swellir g and the progression of articular bone destruction in adjuvant arthritic rats, ten per each, maintained on the diet containing the respective drugs at 0.25% for 10 weeks.
Kamikihito was the most effective, and the inhibition of AA was fairly comparable to that produced by indomethacin in a daily dose of 0.5 mg/kg for the identical period. The data presented suggest that Kampo drugs may be useful for the prophylaxis and treatment of rheumatoid arthritis.
