Abstract
The effect of mizoribine (MZR), an immunosuppressive agent on adjuvant arthritis in rats was investigated. The drug was administrated continuously 28 days after immunization with complete adjuvant.
Twice daily p.o doses of 5 or 10 mg/kg of MZR showed a marked inhibition of swelling in hind legs. Moreover mizoribine treatment improved the bone lesion of hind legs. In mizoribine treatment, a decrease of alkaline phosphatase and an increase of serum albumin-globulin ratio was suppressed and the change of wet weight of thymus, spleen, adrenal and liver tissues were inhibited.
