抄録
The effects of natural and recombinant interferon-α (IFN-α) on osteoclast-like cell formation were tested in human cord blood cultures. Each type of interferon inhibited osteoclast-like cell formation. Natural type IFN-α was a more potent inhibitor of multinucleated cell formation than was recombinant IFN-α. IFN-α also inhibited osteoclast-like cell formation from human cord blood cultures treated with 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3], interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) which are potent stimulators for osteoclasts. These data demonstrate that IFN-α inhibits multinucleated osteoclast-like cell formation, and further suggest that IFN-α may be useful therapeutic agents in diseases such as inflammately bone resorption in which cytokines (IL-1β. IL-6, TNF-α) have been associated.
