抄録
The inhibitory influences of indomethacin (IND) and proglumetacin maleate (PGM) on prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) activities in synovial fluid in osteoarthritis (OA) were investigated. Clinically, no significant difference was observed in final global improvement rate between IND and PGM groups. PGM group showed an improvement higher than IND group in joint effusion. IND showed selective inhibition of PGE2 formation, but caused a increase in LTB4 formation. On the other hand, PGM showed a almost same inhibitory effects both on PGE2 and LTB4 formation.
These results indicated that PGM, so called dual inhibitor, had a dual inhibitory effects on cyclooxy-genase and lipoxygenase in vivo.
