抄録
TA-383 inhibited significantly IL-1 production by peripheral blood mononuclear cells and monocytes from healthy volunteers. The inhibitory effect of TA-383 was recognized more distinctly in monocytes as compared to mononuclear cells. The inhibitory effect of TA-383 on IL-1 production by monocytes from rheumatoid arthritis (RA) patients was comfirmed by both lymphocyte activating factor assay and ELISA. The proliferation of synovial cells from RA patients was suppressed by TA-383.
These results suggest that TA-383 is expected to be useful as DMARD.
