Abstract
The effect of direct irritant action of anti-inflammatory powder drugs (all 25mg) in canine gastric mucosa was studied using an endoscopic compressed air drug delivery system technique. Aspirin-induced mucosal lesions were limited to the target site of gastric mucosa in all dogs. Indomethacin (30%) and diclofenac Na (40%) induced superficial gastritis at the pyloric antrum, but did not appear to spray sites. Predonisolone caused the erosion and edema throughout the stomach. No lesions were induced by lactose and sucralfate.
In the present study, we could observe the experimental gastric mucosal lesion at the target site of the gastric mucosa by an administration of a small amount of powdered drugs via an endoscope. The administration of powdered drugs by endoscopy is useful for the investigation of direct effects of those on the gastric mucosa.
