Abstract
The antiinflammatory and antiallergic effects of CE were evaluated by measuring antigen-induced histamine release from leukocytes and the following results were obtained. (1) CE inhibited his-tamine release from leukocytes at dose dependent manner. (2) Homoaromoline, cepharanoline and aromoline also inhibited antigen-induced histamine release stronger than CE and isotetrandrine sup-pressed histamine release but its suppression was not dose dependent. (3) Cepharanthin, berbamine and cycleanine did not inhibit histamine release from leukocytes with dose dependency.
These results suggest that the main sources of anti-allergic effect of CE were in homoaromoline, aromoline and cepharanoline.
