Abstract
Acute lung injury is known as ARDS, wet lung syndrome, Da Nang lung and capillary leak syndrome. The cause of acute lung injury are aspiration pneumonia, viral and bacterial pneumonia, toxic gas inhalation and pulmonary thromboembolism. Alveolar macrophages are activated by various exogeneous stimuli and various chemical mediators including PGE2, PGI2, LTB4, LTC4, LTD4, 5-HETE and TxB2are released. Recruitment of neutrophils to pulmonary vascular beds is induced by LTB4, IL-7, complement C5a and PAF released from alveolar macrophages. Neutrophils adhered to the inner surface of pulmonary vascular beds induced by adhesion molecules, then release LTB4, elastase, PAF and free radicals. These substances injure lung tissues and acute lung injury occurs.
