Effect of azelastine, an anti-allergic compound, on granulocyte-endothelial cell adhesive reactions induced by PAF was investigated using human granulocytes and human umbilical vein endothelial cells. Azelastine inhibited surface expression of CD18 on granulocytes induced by PAF. In addition, azelastine reduced CD18-dependent granulocyte adherence to endothelial cells elicited by PAF.
These results indicate that azelastine has an anti-inflammatory action through inhibiting granulocyte-endothelial cell interactions at inflammatory site.
