Effect of ciprofloxacin on histamine release from human and rat mast cells

Abstract

The effect of ciprofloxacin (CPFX), one of newquinolones, on histamine release from human dispersed skin mast cells and rat peritoneal mast cells was evaluated in vitro. It was demonstrated that CPFX did not induce significant histamine release from the relevant cells with the concentrations below 20μg/ml, indicating that CPFX itself does not activate mast cells directly as a nonimmunological stimuli with the dosis employed clinically.