Abstract
In acute inflammatory responses, a series of adhesive interactions occurs consecutively between circulating leukocytes and vascular endothelial cells of inflamed tissues. Recent studies have demonstrated that this leukocyte-endothelial adhesion cascade is mediated by a number of adhesion molecules and that the controlled inhibition of the adhesion cascade results in significant suppression of inflammatory and/or immune responses. Here we summarize our own attempts in such antiadhesion therapy in various experimental animal models and discuss its potential, limitation and future perspective.
