炎症
Online ISSN : 1884-4006
Print ISSN : 0389-4290
ISSN-L : 0389-4290
末梢血中好中球のnatural cytotoxicity活性とADCC活性
大原 守弘白土 雅美宮田 昌之熊川 宏美佐久間 博史七宮 実吉田 直衛吉田 浩粕川 禮司
著者情報
ジャーナル フリー

1983 年 3 巻 1 号 p. 23-27

詳細
抄録
Cytotoxic activity of peripheral polymorphonuclear-leukocytes (PMN) of normal subjects and patients with various diseases was tested against K 562 cells for natural cytotoxicity and P 815 cells for ADCC by means of 51Cr-releasing assay incubated for 14 hours. Natural cytotoxicity of PMN of 20 normal subjects was 5.0% at a mean value. Mean values of PMN natural cytotoxiciy of patients with asthma, rheumatoid arthritis (RA), chronic hepatitis (CH), malignancy, Behçet's disease and SLE weel 10.8%, 4.7%, 1.2%, 1.8% and 1.5% respectively. ADCC activity of normarl PMN was 16.0% at a mean value. Mean values of PMN ADCC activity of patients with asthma, RA, CH, malignancy, Behçet's disease and SLE were 2.6%, 4.9%, 35.7%, 15.0%, 24.5% and 34.4% respectively. Natural cytotoxicity of PMN was around 1/6 of that of lymphocytes and ADCC activity of PMN was around 1/2 of that of lymphocytes. However, in all 4 patients with SLE and 2 of patients with Behçet's disease, ADCC activities of their PMN were higher than those of their lymphocytes.
著者関連情報
© 日本炎症・再生医学会
前の記事 次の記事
feedback
Top