Abstract
The values of plasma 6-keto-PGF1α, metabolite of prostacyclin and basal level of platelet prostanoids were measured by RIA, before and during PGE1 administration and just after and one week after completion of the treatment to seven collagen disease patients (2 cases of PSS, 1 case of SLE, MRA, Behçet, PN and MCTD) and 2 cases of Buerger's disease and 6 cases of diabetes mellitus as the control of non-inflammatory diseases, and the following results were obtained: 6-Keto-PGF1α values in plasma and both iPGE values and E/F ratio in platelet suspensions were decreased significantlly just after and one week after completion of PGE1 treatment, in both collagen disease patients and control subjects. These results indicate that the clinical effect of PGE1 treatment in peripheral vascular diseases may result from improvements of both hypoxia in organs and hyperaggreable state of platelet.
