Changes in leukocytes in peritoneal exudates and blood and vascular permeability of mice after glycogen administration

Abstract

Kinetics of inflammatory cell accumulation in mice in response to glycogen and influence of protease inhibitors and anti-inflammatory drugs were studied. Leukocytes in blood maximally increased at 2 hr after glycogen injection. The maximum cell accumulation in the peritoneal cavity was observed at 8 hr, whereas the protein content in the peritoneal exudate reached the maximum level at 1-2 hr and then decreased. Among drugs examined, indomethacin and dexamethasone suppressed markedly the accumulation of white cells and protein exudation.