Abstract
The pathogenesis of anaphylactic shock is still a matter of speculation. In present investigation we measured blood level of leukotriene (LT) and thromboxane B2 (TxB2) in an anaphylactic shock induced by the intravenous infusion of ascaris antigen and studied the effect of OKY-046, thromboxane A2 synthetase inhibitor, on the change of blood level of LT and TxB2 in anesthetized dogs.
Mongrel dogs, weighing about 10 kg, were anesthetized with intravenous administration of 25mg/kg of sodium pentobarbital.
(1) Anaphylactic shock-induced fall in Psyst was inhibited, while the increase of Ptr was not inhibited by the pretreatment with OKY-046.
(2) Plasma level of TxB2 showed a significant increase and reached a maximum value 30 min. after the antigen challenge, but such and increase was suppressed significantly by the pretreatment with OKY-046.
(3) Total amount of LTs in blood showed a significant increase and reached a maximum value 10 min. after the antigen challenge, and such an increase was not suppressed by the pretreatment with OKY-046.
Above results may suggest that TxA2 did not show any significant role in the mechanism of Ptr increase in an ascaris antigen-induced anaphylactic shock.
