Vasoconstrictory action of leukotriene D₄ (LTD₄) on the denuded coronary arteries in mongrel dogs

Abstract

To clarify the vasoconstrictory action of leukotriene D₄ (LTD₄) on the injured coronary arteries, 8 mongrel dogs were denuded by basket balloon catheter (denuded group) and LTD₄ (0.33μg) was directly administered into left anterior descending coronary artery. Hemodynamic parameters as well as epicardial ECG were recorded after LTD₄ administration. Another 8 non-denuded dogs were served as control.
Furthermore, the influence of denudation to LTD₄-induced coronary spasm was determined by coronary arteriography (CAG) . In results, a significant reduction of coronary blood flow (from 1.03±0.13 to 0.49±0.05 ml/kg/min. P<0.01) and a significant increase of coronary vascular resistance (from 6.5±1.0 to 12.7±2.5 mmHg/ml/min. P<0.01) concomitant with a marked prolongation of ST segment elevation on epicardial EGG (duration time 439±86 sec) were observed in denuded group as compared with non-denuded group. And, the exaggeration of LTD₄-induced coronary spasm at the site of denudation was documented by GAG.
These results suggested that the vasoconstrictory action of LTD₄ was exaggerated on the injured coronary arteries and which might play an important role of pathogenesis and deteriolation of myocardial ischemia.