抄録
To clarify the vasoconstrictory action of leukotriene D4 (LTD4) on the injured coronary arteries, 8 mongrel dogs were denuded by basket balloon catheter (denuded group) and LTD4 (0.33μg) was directly administered into left anterior descending coronary artery. Hemodynamic parameters as well as epicardial ECG were recorded after LTD4 administration. Another 8 non-denuded dogs were served as control.
Furthermore, the influence of denudation to LTD4-induced coronary spasm was determined by coronary arteriography (CAG) . In results, a significant reduction of coronary blood flow (from 1.03±0.13 to 0.49±0.05 ml/kg/min. P<0.01) and a significant increase of coronary vascular resistance (from 6.5±1.0 to 12.7±2.5 mmHg/ml/min. P<0.01) concomitant with a marked prolongation of ST segment elevation on epicardial EGG (duration time 439±86 sec) were observed in denuded group as compared with non-denuded group. And, the exaggeration of LTD4-induced coronary spasm at the site of denudation was documented by GAG.
These results suggested that the vasoconstrictory action of LTD4 was exaggerated on the injured coronary arteries and which might play an important role of pathogenesis and deteriolation of myocardial ischemia.
