Stimulated production of active oxygen with anti-microsome antibody positive sera in Basedow's disease

Abstract

To evaluate pathophysiological significance of anti-microsome antibody positive sera in Basedow's disease, we have examined the production of opsonized zymosan stimulated active oxygens in neutrophils and the chemotaxis stimulated by f-methyonylleucyl-phenylalanine. O^-₂ significantly increased with sera of Basedow's disease as compared with those of healthy subjects. However OH^⋅ production and chemotaxis have not significantly changed.
Productive-stimulating factors are, therefore, suggested to be present in the sera of Basedow's disease. The association of the factors with hyperthyroidism was discussed.