抄録
After the treatment of thermal injury, contents of leukotriene C4 (LTC4) increased significantly at early stage and then kept the high level of LTC4 during the inflammation. Administration of vitamin A (VA) on vitamin A deficient- (AD) rats suppressed LTC4 induction in the lung and also inflammation and then gradually induced the significant decrease of LTC4 contents to the normal level 3 days after treatment of thermal injury. Synthesis of 6KPGF1α in the lung of AD rat was induced gradually until 24 hours after thermal injury. While the administration of VA to AD-rat enabled in the lung to induce the synthesis of 6-KPGF1α enough at early stage of thermal injury. After this induction, the production of 6KPGF1α gradually decreased. These results suggest that VA will suppress specifically the induction of lipoxygenase products but will not interfere the synthesis of cyclooxygenase products.
