Abstract
Myofibroblasts (MFb) were isolated from scar tissue in rat oral mucoperiosteum and cultured in vitro. Collagen synthesizing activity in the MFb was compared with that in fibroblasts (Fb) derived from normal tissue. In the present study, collagen synthesizing activity in MFb was higher than that in Fb. On the other hand, no significant difference was found in non-collagen protein synthesizing activity between MFb and Fb. As a result, the ratio of the synthesizing activity of collagen to that of total protein was higher in MFb than Fb. Collagen type analysis showed that Type III/Type I ratio was higher in MFb than in Fb.
