抄録
When the cytokines, such as interleukin-1 (IL-1) and/or tumor necrotizing factor (TNF), are inocculated into the culture of human endothelium, the tissue plasminogen activator is lower and the tissue plasminogen activator inhibitor (PAT-1) is higher in the supernatant of the culture system than without inocculation. In addition, tissue type of coagulation factor is increased, suspecting the acceleration of fibrin formation in the course of inflammation. On the other hand, the plasminogen activator, which is an UK type activator, is derived from the monocytes/macrophages by the stimulation of substances such as thioglycolate, endotoxin and others which are related to the inflammation. Fibrinolysis and coagulation in inflammation are not necessarily unipolar. We need further information to be able to adequately explain the changes of tPA in Kawasaki disease which is one of the most severe vasculitis disorders in infants.
