Abstract
Extracts of articular cartilage from patients with osteoarthritis were shown to contain plasminogen activators (PA) . Two types of PA were detected on SDS-polyacrylamide gel electrophoresis followed by fibrin overlay technique. Cartilage derived PAs with Mr 53 K and 33 K were immunologically identical to urokinase type PA, and PAs with Mr 67 K, 72 K and 95 K were immunologically identical to tissue type PA, for the lysis bands of these cartilage derived PAs were quenched by addition of specific antibodies to fibrin gels.
