炎症・再生
Online ISSN : 1880-5795
Print ISSN : 1346-8022
ISSN-L : 1346-8022
抗原誘発気道好酸球浸潤におけるJak2とStat5の役割
中島 裕史岩本 逸夫
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ジャーナル フリー

2001 年 21 巻 1 号 p. 55-62

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We studied the role of Jak 2 and Stat 5 in antigen-induced eosinophil recruitment into the airways of sensitized mice. The in vivo administration of a Jak 2 inhibitor AG-490 prevented antigen induced eosinophil recruitment into the airways of sensitized mice in a dose-dependent manner, whereas the administration of AG-490 did not affect antigen induced IL-5 production in the airways. On the other hand, both antigen induced IL -5 production and antigen induced airway eosinophilia was diminished in Stat 5 a-deficient (Stat 5 a-/-) mice and Stat 5 b-deficient (Stat 5 b-/-) mice. In addition, eosinophilopoiesis induced by the administration of recombinant IL-5 was diminished in Stat 5 a-/- mice and Stat 5 b-/- mice. Interestingly, antigen-induced Th 2 cell differentiation was decreased but antigen-induced Th 1 cell differentiation was increased in Stat 5 a-/- mice. Together, these results indicate that Jak 2 and Stat 5 activation are essential for the induction of IL-5-dependent, antigen-induced eosinophil recruitment into the airways and that the defects in antigen induced eosinophil recruitment in Stat 5 a-/- mice and Stat 5 b-/- mice result from both impaired IL -5 production in the airways and diminished IL -5 responsiveness of eosinophils.

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