慢性関節リウマチ患者関節液中T細胞のII型コラーゲン反応性
1993 年 12 巻 1 号 p. 73-82
詳細
1993 年 12 巻 1 号 p. 73-82
In order to define the importance of type II collagen (C-II) in the activation of rheumatoid arthritis (RA) synovial fluid (SF) T cells, the proliferative response of these cells to C-II was examined. In 6 of 23 RA patients, SF T cells showed strong responses to C-II. Twelve clones from those SF T cells were established to assess the response of individual T cells. One of the clones showed a strong response to both collagen type I and type II as well as to purified protein derivative. Phenotypic analysis revealed it to have γδ T cell receptors. These results suggest that T cell response to autologous antigen plays an important role, at least in some patients with RA, in the development and persistance of rheumatoid synovitis.
