抄録
The bone mineral content in skeletal bones seems to be decreased due to the implication of abnormal calcium regulating hormones in the destructive change of bones in patients with rheumatoid arthritis (RA) . This study shed light on the clarification of the relationship between calcium regulating hormones and bone mineral content in axial bone and the bone change in phalanx bone. The bone mineral content (QCT) in axial bone was measured with computed tomography and the bone change in phalanx bone was done with microdensitometry in patients with RA and osteoporosis. Bone metabolic markers such as bone GLA-protein (BGP), mainly c-terminal and mid-region recognized parathyroid hormone (p-PTH-84), and intact PTH 1-84 were also assayed in patients with RA.
The decrease of QCT values in females with RA was shown at an earlier age than that in females with osteoporosis. But no significant difference in QCT values in the patients with RA and osteoporosis in the eighty-year-old group was recognized. The bone change indices in phalanx bone such as width of cortex (MCT) and sigma GS/D in RA patients over 50 years old were more increased than those of female patients with osteoporosis at the same age. The more destructive bone changes there were in patients with RA, the more increased was the bone metabolic maker.
From these results it could be concluded that the decrease of bone mineral content in axial bone and destructive changes in axial bone seemed, in part, to be responsible for abnormal calcium regulating hormones.
