Journal of Clinical and Experimental Hematopathology
Online ISSN : 1880-9952
Print ISSN : 1346-4280
ISSN-L : 1346-4280
Original Article
TET2 mutation in diffuse large B-cell lymphoma
Yoko KubukiTakumi YamajiTomonori HidakaTakuro KamedaKotaro ShideMasaaki SekineAyako KamiuntenKeiichi AkizukiHaruko ShimodaYuuki TahiraKenichi NakamuraHiroo AbeTadashi MiikeHisayoshi IwakiriYoshihiro TaharaMitsue SuetaShojiro YamamotoSatoru HasuikeKenji NagataAkira KitanakaKazuya Shimoda
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2017 Volume 56 Issue 3 Pages 145-149

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Abstract

Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. TET2 mutation presents across disease entities and was reported in lymphoid malignancies. We investigated TET2 mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.

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© 2017 by The Japanese Society for Lymphoreticular Tissue Research
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