酵素電顕的peroxidase活性からみたヒト腹腔マクロファージの婦人科疾患における動態

抄録

Macrophages (Mφ) obtained from the pelvic cavity of 30 patients with various gynecological diseases were investigated enzyme-cytochemically to examine stimulatory conditions of the cavity. Resident Mφ, exudate Mφ, exudate-resident Mφ and peroxidase (PO)-negative Mφ were distinguished in the human peritoneal Mφ populations as in animal species. In many cases of the present series, PO-negative Mφ predominated in human peritoneal Mφ population, and resident Mφ were present in a few cases. These results indicate that the peritoneal cavity of woman may be stimulated persistently by unknown local factors. Exudate Mφ were more numerous in the peritoneal cavity of patients with ovarian carcinoma than in that of other patients. In patients with endometrial carcinoma, cervical carcinoma and benign ovarian tumor, Mφ, especially exudate ones, were few in number.
From these results, ultrastructural PO-cytochemistry of human peritoneal Mφ is considered to be useful for analyzing stimulatory state of the peritoneal cavity in the patients with various gynecological diseases.