Abstract
Reconstructed secondary lymphoid follicles (LFs) in lymph nodes and spleens in severe combined immunodeficiency (SCID) mice (H-2d) were observed, which were grafted by bone marrow cells obtained from CB-17 mice (H-2d), C3H mice (H-2k), and Wistar rats, followed by antigenic stimulations. The secondary LFs reconstituted with bone mar-row cells obtained from CB-17 mice contained functionally active follicular dendritic cells (FDCs) capable of trapping and further retaining of mouse peroxidase anti-peroxidase as immune complex. Cell grafting study on SCID mice using C3H mouse- and Wistar rat-bone marrow cells demonstrated that FDCs in reconstituted LFs exhibited makers specific for SCID mice, but not for donar animals. These data do not suggest the bone marrow cell origin of FDCs.
