日本リンパ網内系学会会誌
Online ISSN : 1883-681X
Print ISSN : 1342-9248
ISSN-L : 1342-9248
蛋白漏出性胃腸症と汎血球減少症を合併した脾臓原発組織球性肉腫の一例
牧島 秀樹北野 喜良
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ジャーナル フリー

2000 年 40 巻 4 号 p. 205-210

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A 68-year-old female was hospitalized because of general fatigue and edema. Physical examination revealed anemia and splenomegaly, and laboratory tests showed severe hypoproteinemia and pancytopenia. She was splenectomized and diagnosed as histiocytic sarcoma showing diffuse infiltration of large histiocytic cells (LCA-, CD45RO-, CD20-, CD15-, CD30-, CD35-, CD68+ FDC+, fascin+). While any test including gastrointestinal endoscopy and bone marrow cytology did not detect infiltration of the sarcoma cells, hypoproteinemia and pancytopenia continued after splenectomy. An alpha anti-trypsin test revealed protein-losing gastroenteropathy. Despite of CHOP therapy-resistance, treatment with etoposide and prednisolone improved hypoproteinemia and pancytopenia.

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