Hodgkin's disease

Past, Present and Future

Abstract

In the past decades, significant progresses have been made in the field of research on Hodgkin's disease^{1, 2}. Results obtained by the single cell analysis of Reed-Sternberg's cells on tissue sections, radically changed our understanding of this ever-debated disease³. Discovery of disturbed functions in some transcription regulatory factors also much clarified the pathophysiology of this disease. In this paper, a brief history and the molecular mechanisms of Hodgkin's disease so far understood will be reviewed.