A Case Report showing Effectiveness of PDT (Photodynamic Therapy) for a CIS (Carcinoma in situ) Patient with Condyloma of the Uterine Cervix

Abstract

HPV infection causes benign lesion such as condyloma or malignant lesion such as cervical cancer depending on HPV genotype. Therapeutic methods against condyloma are medication and surgical treatment, but effectiveness of PDT against condyloma is not clear.
We report here a 34-years-old case with both CIS and condyloma of the uterine cervix at the same time. Both HPV (Human papilloma virus) type 6 and 16 were detected by using HPV genotyping method, i.e., Amplicore linear array. We treated that patient by PDT after obtaining the informed consent from her and her family. The therapeutic effect of PDT was rated as CR (complete response) and HPV viruses were not detected 6 months after PDT. She had no recurrence for one year after PDT. Simultaneous infection of high- and low-risk HPVs at the uterine cervix might have caused CIS and condyloma at the same time. It was suggested that PDT might be effective on the case with CIS even complicated with condyloma of the uterine cervix.