The Journal of Japan Society for Laser Surgery and Medicine
Online ISSN : 1881-1639
Print ISSN : 0288-6200
ISSN-L : 0288-6200
Current issue
Displaying 1-15 of 15 articles from this issue
New Developments in Photoacoustic Imaging
REVIEW ARTICLE
  • Takeshi Hirasawa, Tomohiro Ishikawa, Ryo Shintate, Manami Miyashita, M ...
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 365-373
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 27, 2024
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    Optical resolution photoacoustic microscopy (OR-PAM) is a microscopic imaging technique that allows the three-dimensional distribution of optical absorbers near the surface of biological tissues to be visualized. Hemoglobin and melanin, which are the primary imaging targets for OR-PAM, are visualized separately by acquiring OR-PAM images at multiple excitation wavelengths. However, the time difference of several seconds to minutes between the excitation wavelengths poses several challenges. To address this challenge, we developed high-speed spectroscopic photoacoustic imaging technology that can obtain spectroscopic information on an imaging target in a single image acquisition. In this article, the recent trends in OR-PAM research and theory of high-speed spectroscopic photoacoustic imaging technology are presented.

COMMENTARY
  • Taiichiro Ida, Koji Mizukoshi
    Article type: COMMENTARY
    2025 Volume 45 Issue 4 Pages 374-379
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 21, 2024
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    While ultrasound imaging is a structural imaging method that images the structure of the measurement object by the difference of hardness, photoacoustic imaging is characterized by its functional imaging method that uses the characteristics of light to selectively image objects that absorb light, such as blood vessels. We have developed a photoacoustic and high-frequency ultrasound microscope HadatomoTM Z, which can simultaneously visualize skin structure and blood vessel network. We report the analysis results of measurements carried out by the developed system on several healthy volunteers, and the relationship between the skin structure and blood vessel images.

REVIEW ARTICLE
  • Yasuyuki Tsunoi
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 380-387
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: January 07, 2025
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    Accurate assessment of burn severity is crucial to determine treatment plans for burn patients. However, no reliable diagnostic method has been established. Photoacoustic (PA) imaging may be useful for burn diagnosis because it enables depth-resolved visualization of full-thickness skin. This article reviews some recent reports on the application of PA imaging for burn diagnosis as well as our recent research on burn depth assessment by light-emitting diodes (LEDs)-based PA imaging.

  • Yushi Suzuki
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 388-397
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 27, 2024
    JOURNAL FREE ACCESS FULL-TEXT HTML

    Photoacoustic imaging (PAI) utilizes the photoacoustic effect to visualize fine internal structures. Particularly in lymphatic vessel imaging, PAI demonstrates superior performance compared to traditional imaging methods. This paper outlines the principles of PAI, its clinical significance, and existing reports on lymphatic vessel imaging. PAI is beneficial for diagnosing and planning the treatment of lymphedema, and future device improvements are expected to expand its clinical applications further.

  • Ryo Murakami, Shang Gao, Haichong K. Zhang
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 398-408
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 25, 2024
    JOURNAL FREE ACCESS FULL-TEXT HTML

    Photoacoustic (PA) imaging is a technology that combines the high contrast of optical imaging with the deep penetration of ultrasound imaging. By adjusting the wavelength of the laser, it can identify specific tissues and lesions with high sensitivity and specificity. This technology enables the real-time determination of the precise location and condition of tissues during surgery, significantly enhancing the accuracy and safety of treatment. Furthermore, integrating PA imaging with robotics is expected to extend these advantages further, enabling more effective and safer therapeutic interventions.

Recent Advances in Ophthalmic Diagnosis and Treatment Using Laser Technology
REVIEW ARTICLE
  • Miho Nozaki
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 410-416
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 21, 2024
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    Scanning laser ophthalmoscopes have made remarkable progress in the field of ophthalmology in recent years. In particular, the ultra-widefield scanning laser ophthalmoscope that can image 80% of the fundus without mydriasis, which was introduced at the beginning of the 21st century, has greatly changed the style of clinical practice. In addition to color fundus imaging and fluorescein fundus angiography, fundus autofluorescence imaging using laser sources with blue and green wavelengths has established a new diagnostic approach. This review introduces the history, status, and prospects of scanning laser ophthalmoscopes.

  • Teruyo Kida
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 417-424
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: November 28, 2024
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    Laser speckle method is a non-invasive measurement of ocular tissue circulation such as the optic nerve head, choroid, and retina. Here, I would like to introduce some studies by using laser speckle flowgraphy (LSFG). Through our studies including basic and clinical researches, we indicated that ONH circulation was increased by administration of glucose. A high blood glucose level seems to promote ocular capillary circulation and NO as well as insulin appear to have a role in this process. In addition, we observed the behavior of retinal veins in spontaneous hypertensive rats and showed that an increase of ET-1 in circulating blood leads to the local constriction of retinal veins by the real-time monitoring using LSFG-Micro.

  • Yosuke Ueno
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 425-431
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 21, 2024
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    Introducing a review of laser treatment for glaucoma. We will also introduce laser trabeculoplasty, which is commonly performed as a non-invasive surgical treatment in daily clinical practice.

  • Masahiro Yamanari
    Article type: REVIEW ARTICLE
    2025 Volume 45 Issue 4 Pages 432-443
    Published: January 15, 2025
    Released on J-STAGE: January 18, 2025
    Advance online publication: December 25, 2024
    JOURNAL FREE ACCESS FULL-TEXT HTML

    This review presents an overview of contrast mechanisms in polarization-sensitive optical coherence tomography (PS-OCT) and its applications in ophthalmology. The principles of birefringence and depolarization, the primary contrast mechanisms in PS-OCT, are elucidated. The article introduces exemplary applications of PS-OCT in various ocular tissues, including retinal nerve fibers, scar tissue, cornea, sclera, and retinal pigment epithelium. Furthermore, it contextualizes PS-OCT within the broader landscape of OCT technology development and democratization. The review concludes by examining the potential of PS-OCT to offer novel perspectives in ophthalmic diagnosis and research.

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