The Journal of Japan Society for Laser Surgery and Medicine
Online ISSN : 1881-1639
Print ISSN : 0288-6200
ISSN-L : 0288-6200
TOPICAL ARTICLE: Current Trends in Photodynamic Diagnosis and Therapy
Design of Photo-triggered Nitric oxide (NO)-releasing Nanoparticle for Novel Photodynamic Therapy
Yukio Nagasaki
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Keywords: nitric oxide, photo-triggered NO-releasing nanoparticles, apoptosis, nanomedicine, drug delivery system
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2013 Volume 34 Issue 2 Pages 138-140

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Abstract

Core-shell type nanoparticles containing 4-nitro-3-trifluoromethylphenyl units in the core were prepared and their phototriggered nitric oxide (NO)-generating ability was confirmed by the spin trapping method using an electron spin resonance and the Griess method. These nanoparticles were found to deliver exogenous NO into tumor cells in a photocontrolled manner and showed an NO-mediated antitumor effect, indicating the usability of this molecular system in NO-based tumor therapy

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© 2013 Japan Society for Laser Surgery and Medicine
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