Outcome from Photodynamic Therapy with Phospholipid-Conjugated Indocyanine Green for Animal Spontaneous Deep-Seated Occurring Tumors

Yoshiharu Okamoto; Tomohiro Ohsaki; Kazuo Azuma; Norihiko Itoh; Takeshi Tsuka; Tomohiro Imagawa; Akiko Suganami; Yutaka Tamura

doi:10.2530/jslsm.jslsm-35_0008

TOPICAL ARTICLE: Laser Therapy in Veterinary Medicine

Outcome from Photodynamic Therapy with Phospholipid-Conjugated Indocyanine Green for Animal Spontaneous Deep-Seated Occurring Tumors

Yoshiharu Okamoto, Tomohiro Ohsaki, Kazuo Azuma, Norihiko Itoh, Takeshi Tsuka, Tomohiro Imagawa, Akiko Suganami, Yutaka Tamura

Author information

Yoshiharu Okamoto
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
Tomohiro Ohsaki
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
Kazuo Azuma
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
Norihiko Itoh
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
Takeshi Tsuka
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
Tomohiro Imagawa
Department of Veterinary Clinical Medicine, School of Veterinary Medicine, Tottori University
Akiko Suganami
Department of Bioinformatics, Graduate School of Medicine, Chiba University
Yutaka Tamura
Department of Bioinformatics, Graduate School of Medicine, Chiba University

Keywords: dogs and cats, laser, cancer, ICG, liposome

JOURNAL FREE ACCESS

2014 Volume 35 Issue 1 Pages 46-50

DOI https://doi.org/10.2530/jslsm.jslsm-35_0008

Details

Abstract

We synthesized liposomally formulated phospholipid-conjugated indocyanine green (ICG-lipo). Using the ICG-lipo and a broad band light source or diode laser, we tried to treat against 15 cases of animal spontaneous deep-seated occurring tumors. Irradiation was performed for 20-60 min and its intervals were every day or 3 times per week after injection of the ICG-lipo. Outcome of criteria due to RECIST was followed, CR: one case, PR: eight cases, SD: five cases, PD: one case. QOL was improved in all cases with PR and SD. There was no severe side effect.

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