Subcellular localization of novel photosensitizer named porphyrus envelope in human prostate cancer cell line PC-3

Abstract

Photodynamic therapy (PDT), which utilizes laser light and photosensitizer (PS), is now arising as a potential modality for minimally invasive prostate cancer therapy due to its cancer selectivity. However, cancer selectivity and drug accumulation efficiency have to be enhanced to eliminate unwanted side effects and to shorten the time requirement for shielding from light. Therefore, to accomplish high accumulation and selective delivery, we have focused on the drug delivering system of replication-deficient Sendai virus particle, hemagglutinating virus of Japan envelope (HVJ-E). We are currently investigating the therapeutic effectiveness of PDT with a novel photosensitizer named porphyrus envelope, which can be created by combining HVJ-E and PS called protoporphyrin IX (PpIX). This paper will discuss about the drug delivering mechanism of this novel photosensitizer.