2018 Volume 38 Issue 4 Pages 451-456
The mechanism of bactericidal effect of photodynamic therapy (PDT) is considered that photoactivated photosensitizer (PS) accumulated in bacteria generates reactive oxygen species (ROS), and the ROS induce irreversible cell damage to organisms. However, recent investigations have shown that PDT induces other phenomena that support antimicrobial effect, including an activation of host immune cells to phagocyte microorganisms and increase in expressions of growth factors for cellular proliferation. Hence in this short review, we discuss the PDT effects on wound healing, while introducing our recent studies using 5-aminolevuric acid plus light irradiation.
