Usefulness of Photodynamic Diagnosis with Talaporfin Sodium in Surgery for Recurrent High Grade Glioma

Abstract

There are few reports on the fluorescence intensity of photodynamic diagnosis (PDD) with talaporfin sodium (TS) and microscopic visibility at the time of excision. Therefore, we retrospectively examined the relationship between the fluorescence intensity of tumor-specific fluorescence and clinical characteristics of recurrent malignant gliomas. Two of the seven patients who underwent PDD with TS were strongly fluorescent, four had weak fluorescence, and one had no fluorescence. Tumor fluorescence was difficult to distinguish from surrounding tissue in the weakly fluorescent cases. In this study, we found that PDD with TS clearly confirmed tumor-specific fluorescence in strongly fluorescent-positive cases. However, it is difficult to use PDD with TS as well as 5ALA to improve the extent of resection in recurrent malignant gliomas surgery. Further research is needed to enhance the tumor specific fluorescence.