In silico Evaluation Based on Tissue Optics for Picosecond Laser Treatment of Pigmented Lesions

Abstract

Picosecond lasers have been used in plastic surgery, dermatology, and cosmetic surgery. While the appropriate setting of irradiation endpoints is crucial for effective treatment, laser-induced skin reactions vary not only with irradiation parameters but also with skin type and lesion distribution in the skin. In silico evaluation based on tissue optics is effective for analyzing the picosecond laser-skin interactions, taking these factors into account. This article reviews an in silico evaluation based on tissue optics for picosecond laser treatment of pigmented lesions, including an in silico model of picosecond laser treatment, measurement of optical properties of human skin, computational design of an irradiation indicator, and validation of in silico results by comparison with the results from clinical studies.