Abstract
We investigated the distribution of pheophorbide a (Phd) and 10-hydroxypheophorbide a (OH-phd) in organs of sarcoma 180-bearing mice after intravenous (iv) administration at the dose of 10mg/kg.
The blood concentration of Phd and OH-phd (Phds) showed the high-level at lhr after iv administration, then rapidly decreased, and disappeared at 24hr.
Phds distributed mainly in the liver, spleeen, lung, kidney, gastrointestinal tract and tumor tissue, then decreased with the course of time.
OH-phd as compared with Phd, was excreted rapidly from all normal organs and not detected at 48hr after iv administration, but remained in the tumor tissue preferentially even at 96hr.
