Studies on photodynamic therapy with Hematoporphyrin Derivative for treatment of atheromatous lesion,especially, by percutaneous transluminal laser irradiation.

Abstract

This experiment was studied for examining the possibility of safety making atherosclerotic foci regress with photodynamic therapy (PDT) using Hematoporphyrin Derivative (HpD). The 2% cholesterol feeded rabbits were devided into two groups, that is, group C and group H. The group C is consisted of rabbits non-treated with HpD and the group H treated with HpD. The argon dye laser introduced by fiber was irradiated on the atheromatous lesion of abdominal aorta in vivo. These rabbits were sacrificed immediately,2 and 7 days. In the group C, any change was not recognized in the atheromatous lasion of aorta. However, in the group H, the endothelial and intimal cells were distructed by laser irradiation. From the above data, it is suggested that PDT may be effective for treatment of atheromatous lesion of artery.