The Comparison of the Anti-tumor Effect by Various Photosensitizers after Photodynamic Therapy in Vitro

Abstract

The photosensitizing efficiency per an absorbed photon was compared among three photosensitlzers by the parameters of cytotoxic effect of the tusor cells in vitro. The efficiency of HpO is stronger than that of Photofrin II, and PH-1126 showed a little photosensitizing efficiency. And HpO also showed the highest nuclear DNA dasage In the study using fluorescence cytophotouetory.
However, PH-1125 cost inhibited the Increase of cell numbers as a total dose at least for 2-3 days after photoirradiatlon, because the concentration of PH-1126 Incorporated into the cells was very high.